A team of chemists at the University of Cambridge has developed a metal-free way to convert symmetrical diols selectively into one of two mirror-image isomers. In their paper published in the journal Science, the group took advantage of the ability of chiral versions of quinuclidine—which were derived from Cinchona alkaloids—to catalyze the dememorization of meso-diols under a blue light in conjunction with a photocatalyst and extract hydrogen atoms from symmetrical molecules.
Noting that transferring
hydrogen atoms between molecules is a fundamental chore in
modern chemistry, the research team looked to make the process more selective by adding enantioselective hydrogen atom transfer, where one of the enantiomers of a chiral product is preferentially produced during a chemical reaction.
Their work involved the development of a new method for enantioselective hydrogen atom abstraction—one that allowed for the introduction of chirality into the process. Through their use of catalysts derived from the Cinchona alkaloid family, they were able to exploit the resulting chiral amine structure to selectively remove a hydrogen atom from a specific carbon center in a meso-diol.
They did this by focusing on the use of chiral quinuclidine compounds from Cinchona alkaloids, which allowed them to catalyze the desymmetrization of meso-diols with
blue light and a photocatalyst.
The method used by the team allowed for selective epimerization, which is where one stereoisomer was transformed into another—by replacing a hydrogen atom with a thiol. At the outset, the catalyst, which was made through the direct
hydrogenation of a Cinchona alkaloid, was not very reactive or as selective as hoped.
Further work, however, showed that changing the
hydroxyl group to a protected amine and reversing the stereocenter could improve the catalyst's performance significantly.
The researchers point out that their work is a proof of principle, noting that parts of their technique allow for swapping out the quinuclidine and using the chiral version instead. They also note that the
catalyst could be used for site-selective chemistry if appropriate. They conclude by suggesting their work could have important implications for pharmaceutical applications, and possibly in other research efforts.
Analytical Chemistry Excellence, Scientific Innovation Awards, Analytical Method Development, Instrumental Analysis Innovation, Cutting-Edge Analytical Techniques, Chemistry Research Achievements, Analytical Science Recognition, Advanced Analytical Tools, Chemical Analysis Awards, Global Chemistry Awards
Analytical Chemistry Excellence
Scientific Innovation Awards
Analytical Method Development
Instrumental Analysis Innovation
Cutting-Edge Analytical Techniques
Chemistry Research Achievements
Analytical Science Recognition
Advanced Analytical Tools
Chemical Analysis Awards
Global Chemistry Awards
#AnalyticalChemistryAwards
#ChemistryInnovation
#ScientificExcellence
#AnalyticalTechniques
#ChemistryAwards2024
#GlobalScienceRecognition
#BreakthroughChemistry
#ChemistryResearch
#AnalyticalScience
#AwardWinningResearch
#CuttingEdgeScience
#ChemistryPioneers
#ScienceForSustainability
#TopChemists
Award Information - International Analytical Chemistry Awards
Welcome to the International Analytical Chemistry Awards - International Analytical Chemistry Awards, a premier event in the realm of International Analytical Chemistry Awards. Here's what you need to know about this exciting Award :
- Theme: The theme for International Analytical Chemistry Awards is "Sustainable International Analytical Chemistry Awards for a Connected Future."
- Hybrid Event: International Analytical Chemistry Awards is an innovative hybrid event, offering two dynamic ways to participate.
.png)
No comments:
Post a Comment